Searchable abstracts of presentations at key conferences in endocrinology

ea0035p760 | Obesity | ECE2014

Worsening of cardiovascular risk with increasing number of components of metabolic syndrome in obese non-diabetic individuals

Wolffenbuttel Bruce , Slagter Sandra , Beek Andre Van , Lutgers Helen , Vliet-Ostaptchouk Jana Van , Klauw Melanie Van der

Introduction: The metabolic syndrome (MetS) is a strong predictor of cardiovascular risk. It is influenced by environmental factors, and its prevalence is high in subjects with obesity.Design: We assessed differences in glucose- and lipid parameters, and hsCRP and microalbuminuria (MA) in obese subjects with and without metabolic syndrome (MetS) in LifeLines, a population-based study. Included were subjects 18–80 years, with BMI>30 kg/m2</s...

ea0035p761 | Obesity | ECE2014

Health-related quality of life relates to obesity and low-grade inflammation in obese individuals

Slagter Sandra , Wolffenbuttel Bruce , Beek Andre Van , Lutgers Helen , Vliet-Ostaptchouk Jana Van , Klauw Melanie Van der

Introduction: Obesity is increasingly prevalent in Western society. In addition to medical consequences, obesity also affects health-related quality of life (HR-QOL).Design: We assessed the differences in HR-QOL in obese participants with and without metabolic syndrome (MetS), by level of obesity and level of inflammation, in the LifeLines Cohort study, a population-based study. In total, 12 765 subjects age 18–80 years, with BMI >30 kg/m2<...

ea0041ep779 | Obesity | ECE2016

Skin autofluorescence is associated with the metabolic syndrome and its individual components

van Waateringe Robert , Slagter Sandra , van Vliet-Ostaptchouck Jana , Graaff Reindert , van der Klauw Melanie , Paterson Andrew , Lutgers Helen , Wolffenbuttel Bruce

Background: Skin autofluorescence (SAF) has been demonstrated to be associated with long-term cardiovascular complications in subjects with either diabetes or renal failure. Since the metabolic syndrome (MetS) is a risk factor for cardiovascular disease, the aim of the study was to assess the association between SAF and MetS as well as its individuals components.Materials and methods: For this cross-sectional analysis, we included subjects 18–80 yea...

ea0037gp.14.01 | Diabetes and obesity – Clinical diabetes | ECE2015

What components drive the metabolic syndrome? Results from the population-based LifeLines Cohort Study

Slagter Sandra N , Waateringe Robert P van , Wendker Marjolein , Vliet-Ostaptchouk Jana V van , Lutgers Helen L , Beek Andre P van , Klauw Melanie M van der , Wolffenbuttel Bruce H R

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including visceral obesity, dyslipidaemia, hypertension and impaired fasting glucose. It is also strongly associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes. We assessed which factors contribute to the prevalence of MetS in people within different weight and age categories.Methods: 64 046 western European participants aged 18–80 ...